Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.
Identifieur interne : 000146 ( Main/Exploration ); précédent : 000145; suivant : 000147Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.
Auteurs : F Xavier L Pez-Labrador [Espagne] ; Angels Natividad-Sancho [Espagne] ; Maria Pisareva [Russie] ; Andrey Komissarov [Russie] ; Karina Salvatierra [Espagne] ; Artem Fadeev [Russie] ; Andrés Moya [Espagne] ; Mikhail Grudinin [Russie] ; Javier Díez-Domingo [Espagne] ; Olga Afanasieva [Russie] ; Nadezhda Konovalova [Russie] ; Anna Sominina [Russie] ; Joan Puig-Barberà [Espagne]Source :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de séquence d'ADN (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Espagne (épidémiologie), Femelle (MeSH), Glycoprotéine hémagglutinine du virus influenza (génétique), Grippe humaine (virologie), Grippe humaine (épidémiologie), Génome viral (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Nourrisson (MeSH), Phylogenèse (MeSH), Russie (épidémiologie), Saisons (MeSH), Santé mondiale (MeSH), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (isolement et purification), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Surveillance épidémiologique (MeSH), Variation génétique (MeSH).
- MESH :
- génétique : ARN viral, Glycoprotéine hémagglutinine du virus influenza, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- isolement et purification : Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Espagne, Grippe humaine, Russie.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de séquence d'ADN, Enfant, Enfant d'âge préscolaire, Femelle, Génome viral, Humains, Jeune adulte, Mâle, Nourrisson, Phylogenèse, Saisons, Santé mondiale, Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance épidémiologique, Variation génétique.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Child (MeSH), Child, Preschool (MeSH), Epidemiological Monitoring (MeSH), Female (MeSH), Genetic Variation (MeSH), Genome, Viral (MeSH), Global Health (MeSH), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Humans (MeSH), Infant (MeSH), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (isolation & purification), Influenza, Human (epidemiology), Influenza, Human (virology), Male (MeSH), Middle Aged (MeSH), Phylogeny (MeSH), RNA, Viral (genetics), Russia (epidemiology), Seasons (MeSH), Sequence Analysis, DNA (MeSH), Spain (epidemiology), Young Adult (MeSH).
- MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, RNA, Viral.
- epidemiology : Influenza, Human, Russia, Spain.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype.
- isolation & purification : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Epidemiological Monitoring, Female, Genetic Variation, Genome, Viral, Global Health, Humans, Infant, Male, Middle Aged, Phylogeny, Seasons, Sequence Analysis, DNA, Young Adult.
Abstract
BACKGROUND
Continuous surveillance for genetic changes in circulating influenza viruses is needed to guide influenza prevention and control.
OBJECTIVES
To compare intra-seasonal influenza genetic diversity of hemagglutinin in influenza A strains isolated from influenza hospital admissions collected at two distinct sites during the same season.
STUDY DESIGN
Comparative phylogenetic analysis of full-length hemagglutinin genes from 77 isolated influenza A viruses from the St. Petersburg, Russian Federation and Valencia, Spain sites of the Global Influenza Hospital Surveillance Network (GIHSN) during the 2013/14 season.
RESULTS
We found significant variability in A(H3N2) and A(H1N1)pdm09 viruses between the two sites, with nucleotide variation at antigenic positions much lower for A(H1N1)pdm09 than for A(H3N2) viruses. For A(H1N1)pdm09, antigenic sites differed by three to four amino acids from the vaccine strain, two of them common to all tested isolates. For A(H3N2) viruses, antigenic sites differed by six to nine amino acids from the vaccine strain, four of them common to all tested isolates. A fifth amino acid substitution in the antigenic sites of A(H3N2) defined a new clade, 3C.2. For both influenza A subtypes, pairwise amino acid distances between circulating viruses and vaccine strains were significantly higher at antigenic than at non-antigenic sites. Whereas A(H1N1)pdm09 viruses clustered with clade 6B and 94% of A(H3N2) with clade 3C.3, at both study sites A(H3N2) clade 3C.2 viruses emerged towards the end of the season, showing greater pairwise amino acid distances from the vaccine strain compared to the predominant clade 3C.3.
CONCLUSIONS
Influenza A antigenic variants differed between St. Petersburg and Valencia, and A(H3N2) clade 3C.2 viruses were characterized by more amino acid differences from the vaccine strain, especially at the antigenic sites.
DOI: 10.1016/j.jcv.2016.09.006
PubMed: 27690141
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.</title><author><name sortKey="L Pez Labrador, F Xavier" sort="L Pez Labrador, F Xavier" uniqKey="L Pez Labrador F" first="F Xavier" last="L Pez-Labrador">F Xavier L Pez-Labrador</name><affiliation wicri:level="1"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Publica (CIBER-ESP), Instituto de Salud Carlos III, Spain. Electronic address: F.Xavier.Lopez@uv.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Publica (CIBER-ESP), Instituto de Salud Carlos III</wicri:regionArea><wicri:noRegion>Instituto de Salud Carlos III</wicri:noRegion></affiliation></author><author><name sortKey="Natividad Sancho, Angels" sort="Natividad Sancho, Angels" uniqKey="Natividad Sancho A" first="Angels" last="Natividad-Sancho">Angels Natividad-Sancho</name><affiliation wicri:level="2"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain. Electronic address: angels.natividad@hotmail.co.uk.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author><author><name sortKey="Pisareva, Maria" sort="Pisareva, Maria" uniqKey="Pisareva M" first="Maria" last="Pisareva">Maria Pisareva</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: pisareva@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Komissarov, Andrey" sort="Komissarov, Andrey" uniqKey="Komissarov A" first="Andrey" last="Komissarov">Andrey Komissarov</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: komissarov@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Salvatierra, Karina" sort="Salvatierra, Karina" uniqKey="Salvatierra K" first="Karina" last="Salvatierra">Karina Salvatierra</name><affiliation wicri:level="1"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain. Electronic address: kariales@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia</wicri:regionArea><wicri:noRegion>University of Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Fadeev, Artem" sort="Fadeev, Artem" uniqKey="Fadeev A" first="Artem" last="Fadeev">Artem Fadeev</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: artem.fadeev@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Moya, Andres" sort="Moya, Andres" uniqKey="Moya A" first="Andrés" last="Moya">Andrés Moya</name><affiliation wicri:level="1"><nlm:affiliation>Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain. Electronic address: andres.moya@uv.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia</wicri:regionArea><wicri:noRegion>University of Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Grudinin, Mikhail" sort="Grudinin, Mikhail" uniqKey="Grudinin M" first="Mikhail" last="Grudinin">Mikhail Grudinin</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: grudinin@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Diez Domingo, Javier" sort="Diez Domingo, Javier" uniqKey="Diez Domingo J" first="Javier" last="Díez-Domingo">Javier Díez-Domingo</name><affiliation wicri:level="2"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain. Electronic address: diez_jav@gva.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author><author><name sortKey="Afanasieva, Olga" sort="Afanasieva, Olga" uniqKey="Afanasieva O" first="Olga" last="Afanasieva">Olga Afanasieva</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: olga-afanaseva57@mail.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Konovalova, Nadezhda" sort="Konovalova, Nadezhda" uniqKey="Konovalova N" first="Nadezhda" last="Konovalova">Nadezhda Konovalova</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: konovalova_nadya@mail.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Sominina, Anna" sort="Sominina, Anna" uniqKey="Sominina A" first="Anna" last="Sominina">Anna Sominina</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: anna@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Puig Barbera, Joan" sort="Puig Barbera, Joan" uniqKey="Puig Barbera J" first="Joan" last="Puig-Barberà">Joan Puig-Barberà</name><affiliation wicri:level="2"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain. Electronic address: puig_joa@gva.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27690141</idno><idno type="pmid">27690141</idno><idno type="doi">10.1016/j.jcv.2016.09.006</idno><idno type="wicri:Area/Main/Corpus">00116</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00116</idno><idno type="wicri:Area/Main/Curation">000116</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000116</idno><idno type="wicri:Area/Main/Exploration">000116</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.</title><author><name sortKey="L Pez Labrador, F Xavier" sort="L Pez Labrador, F Xavier" uniqKey="L Pez Labrador F" first="F Xavier" last="L Pez-Labrador">F Xavier L Pez-Labrador</name><affiliation wicri:level="1"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Publica (CIBER-ESP), Instituto de Salud Carlos III, Spain. Electronic address: F.Xavier.Lopez@uv.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Publica (CIBER-ESP), Instituto de Salud Carlos III</wicri:regionArea><wicri:noRegion>Instituto de Salud Carlos III</wicri:noRegion></affiliation></author><author><name sortKey="Natividad Sancho, Angels" sort="Natividad Sancho, Angels" uniqKey="Natividad Sancho A" first="Angels" last="Natividad-Sancho">Angels Natividad-Sancho</name><affiliation wicri:level="2"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain. Electronic address: angels.natividad@hotmail.co.uk.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author><author><name sortKey="Pisareva, Maria" sort="Pisareva, Maria" uniqKey="Pisareva M" first="Maria" last="Pisareva">Maria Pisareva</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: pisareva@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Komissarov, Andrey" sort="Komissarov, Andrey" uniqKey="Komissarov A" first="Andrey" last="Komissarov">Andrey Komissarov</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: komissarov@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Salvatierra, Karina" sort="Salvatierra, Karina" uniqKey="Salvatierra K" first="Karina" last="Salvatierra">Karina Salvatierra</name><affiliation wicri:level="1"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain. Electronic address: kariales@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia</wicri:regionArea><wicri:noRegion>University of Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Fadeev, Artem" sort="Fadeev, Artem" uniqKey="Fadeev A" first="Artem" last="Fadeev">Artem Fadeev</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: artem.fadeev@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Moya, Andres" sort="Moya, Andres" uniqKey="Moya A" first="Andrés" last="Moya">Andrés Moya</name><affiliation wicri:level="1"><nlm:affiliation>Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain. Electronic address: andres.moya@uv.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia</wicri:regionArea><wicri:noRegion>University of Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Grudinin, Mikhail" sort="Grudinin, Mikhail" uniqKey="Grudinin M" first="Mikhail" last="Grudinin">Mikhail Grudinin</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: grudinin@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Diez Domingo, Javier" sort="Diez Domingo, Javier" uniqKey="Diez Domingo J" first="Javier" last="Díez-Domingo">Javier Díez-Domingo</name><affiliation wicri:level="2"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain. Electronic address: diez_jav@gva.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author><author><name sortKey="Afanasieva, Olga" sort="Afanasieva, Olga" uniqKey="Afanasieva O" first="Olga" last="Afanasieva">Olga Afanasieva</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: olga-afanaseva57@mail.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Konovalova, Nadezhda" sort="Konovalova, Nadezhda" uniqKey="Konovalova N" first="Nadezhda" last="Konovalova">Nadezhda Konovalova</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: konovalova_nadya@mail.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Sominina, Anna" sort="Sominina, Anna" uniqKey="Sominina A" first="Anna" last="Sominina">Anna Sominina</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: anna@influenza.spb.ru.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Puig Barbera, Joan" sort="Puig Barbera, Joan" uniqKey="Puig Barbera J" first="Joan" last="Puig-Barberà">Joan Puig-Barberà</name><affiliation wicri:level="2"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain. Electronic address: puig_joa@gva.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author></analytic><series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title><idno type="eISSN">1873-5967</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Epidemiological Monitoring (MeSH)</term><term>Female (MeSH)</term><term>Genetic Variation (MeSH)</term><term>Genome, Viral (MeSH)</term><term>Global Health (MeSH)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza A Virus, H3N2 Subtype (genetics)</term><term>Influenza A Virus, H3N2 Subtype (isolation & purification)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Phylogeny (MeSH)</term><term>RNA, Viral (genetics)</term><term>Russia (epidemiology)</term><term>Seasons (MeSH)</term><term>Sequence Analysis, DNA (MeSH)</term><term>Spain (epidemiology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Analyse de séquence d'ADN (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Génome viral (MeSH)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Phylogenèse (MeSH)</term><term>Russie (épidémiologie)</term><term>Saisons (MeSH)</term><term>Santé mondiale (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term><term>Sous-type H3N2 du virus de la grippe A (génétique)</term><term>Sous-type H3N2 du virus de la grippe A (isolement et purification)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Surveillance épidémiologique (MeSH)</term><term>Variation génétique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Russia</term><term>Spain</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Grippe humaine</term><term>Russie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Epidemiological Monitoring</term><term>Female</term><term>Genetic Variation</term><term>Genome, Viral</term><term>Global Health</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Phylogeny</term><term>Seasons</term><term>Sequence Analysis, DNA</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de séquence d'ADN</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Génome viral</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Phylogenèse</term><term>Saisons</term><term>Santé mondiale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Surveillance épidémiologique</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Continuous surveillance for genetic changes in circulating influenza viruses is needed to guide influenza prevention and control.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To compare intra-seasonal influenza genetic diversity of hemagglutinin in influenza A strains isolated from influenza hospital admissions collected at two distinct sites during the same season.</p></div><div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b></p><p>Comparative phylogenetic analysis of full-length hemagglutinin genes from 77 isolated influenza A viruses from the St. Petersburg, Russian Federation and Valencia, Spain sites of the Global Influenza Hospital Surveillance Network (GIHSN) during the 2013/14 season.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We found significant variability in A(H3N2) and A(H1N1)pdm09 viruses between the two sites, with nucleotide variation at antigenic positions much lower for A(H1N1)pdm09 than for A(H3N2) viruses. For A(H1N1)pdm09, antigenic sites differed by three to four amino acids from the vaccine strain, two of them common to all tested isolates. For A(H3N2) viruses, antigenic sites differed by six to nine amino acids from the vaccine strain, four of them common to all tested isolates. A fifth amino acid substitution in the antigenic sites of A(H3N2) defined a new clade, 3C.2. For both influenza A subtypes, pairwise amino acid distances between circulating viruses and vaccine strains were significantly higher at antigenic than at non-antigenic sites. Whereas A(H1N1)pdm09 viruses clustered with clade 6B and 94% of A(H3N2) with clade 3C.3, at both study sites A(H3N2) clade 3C.2 viruses emerged towards the end of the season, showing greater pairwise amino acid distances from the vaccine strain compared to the predominant clade 3C.3.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Influenza A antigenic variants differed between St. Petersburg and Valencia, and A(H3N2) clade 3C.2 viruses were characterized by more amino acid differences from the vaccine strain, especially at the antigenic sites.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27690141</PMID><DateCompleted><Year>2017</Year><Month>10</Month><Day>16</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5967</ISSN><JournalIssue CitedMedium="Internet"><Volume>84</Volume><PubDate><Year>2016</Year><Month>11</Month></PubDate></JournalIssue><Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title><ISOAbbreviation>J. Clin. Virol.</ISOAbbreviation></Journal><ArticleTitle>Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.</ArticleTitle><Pagination><MedlinePgn>32-38</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1386-6532(16)30539-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcv.2016.09.006</ELocationID><Abstract><AbstractText Label="BACKGROUND">Continuous surveillance for genetic changes in circulating influenza viruses is needed to guide influenza prevention and control.</AbstractText><AbstractText Label="OBJECTIVES">To compare intra-seasonal influenza genetic diversity of hemagglutinin in influenza A strains isolated from influenza hospital admissions collected at two distinct sites during the same season.</AbstractText><AbstractText Label="STUDY DESIGN">Comparative phylogenetic analysis of full-length hemagglutinin genes from 77 isolated influenza A viruses from the St. Petersburg, Russian Federation and Valencia, Spain sites of the Global Influenza Hospital Surveillance Network (GIHSN) during the 2013/14 season.</AbstractText><AbstractText Label="RESULTS">We found significant variability in A(H3N2) and A(H1N1)pdm09 viruses between the two sites, with nucleotide variation at antigenic positions much lower for A(H1N1)pdm09 than for A(H3N2) viruses. For A(H1N1)pdm09, antigenic sites differed by three to four amino acids from the vaccine strain, two of them common to all tested isolates. For A(H3N2) viruses, antigenic sites differed by six to nine amino acids from the vaccine strain, four of them common to all tested isolates. A fifth amino acid substitution in the antigenic sites of A(H3N2) defined a new clade, 3C.2. For both influenza A subtypes, pairwise amino acid distances between circulating viruses and vaccine strains were significantly higher at antigenic than at non-antigenic sites. Whereas A(H1N1)pdm09 viruses clustered with clade 6B and 94% of A(H3N2) with clade 3C.3, at both study sites A(H3N2) clade 3C.2 viruses emerged towards the end of the season, showing greater pairwise amino acid distances from the vaccine strain compared to the predominant clade 3C.3.</AbstractText><AbstractText Label="CONCLUSIONS">Influenza A antigenic variants differed between St. Petersburg and Valencia, and A(H3N2) clade 3C.2 viruses were characterized by more amino acid differences from the vaccine strain, especially at the antigenic sites.</AbstractText><CopyrightInformation>Copyright © 2016 The Author(s). Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>López-Labrador</LastName><ForeName>F Xavier</ForeName><Initials>FX</Initials><AffiliationInfo><Affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Publica (CIBER-ESP), Instituto de Salud Carlos III, Spain. Electronic address: F.Xavier.Lopez@uv.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Natividad-Sancho</LastName><ForeName>Angels</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain. Electronic address: angels.natividad@hotmail.co.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pisareva</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: pisareva@influenza.spb.ru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Komissarov</LastName><ForeName>Andrey</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: komissarov@influenza.spb.ru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salvatierra</LastName><ForeName>Karina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain; Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain. Electronic address: kariales@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fadeev</LastName><ForeName>Artem</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: artem.fadeev@influenza.spb.ru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moya</LastName><ForeName>Andrés</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Joint Units of Infection and of Genomics and Health, FISABIO/Cavanilles Institute for Biodiversity and Evolutionary Biology, University of Valencia, Spain. Electronic address: andres.moya@uv.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grudinin</LastName><ForeName>Mikhail</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: grudinin@influenza.spb.ru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Díez-Domingo</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain. Electronic address: diez_jav@gva.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Afanasieva</LastName><ForeName>Olga</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: olga-afanaseva57@mail.ru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Konovalova</LastName><ForeName>Nadezhda</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: konovalova_nadya@mail.ru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sominina</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research Institute of Influenza, Ministry of Health, Prof. Popov Str. 15/17, St. Petersburg, Russian Federation. Electronic address: anna@influenza.spb.ru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Puig-Barberà</LastName><ForeName>Joan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Avda. de Catalunya, 21, 46020 Valencia, Spain. Electronic address: puig_joa@gva.es.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>09</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Clin Virol</MedlineTA><NlmUniqueID>9815671</NlmUniqueID><ISSNLinking>1386-6532</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D062665" MajorTopicYN="Y">Epidemiological Monitoring</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016679" MajorTopicYN="N">Genome, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014943" MajorTopicYN="Y">Global Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012426" MajorTopicYN="N">Russia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Genomic sequencing</Keyword><Keyword MajorTopicYN="Y">H1N1 subtype</Keyword><Keyword MajorTopicYN="Y">H3N2 subtype</Keyword><Keyword MajorTopicYN="Y">Hemagglutinin glycoproteins</Keyword><Keyword MajorTopicYN="Y">Influenza A virus</Keyword><Keyword MajorTopicYN="Y">Influenza virus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>04</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>09</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27690141</ArticleId><ArticleId IdType="pii">S1386-6532(16)30539-X</ArticleId><ArticleId IdType="doi">10.1016/j.jcv.2016.09.006</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li><li>Russie</li></country><region><li>Communauté valencienne</li></region></list><tree><country name="Espagne"><noRegion><name sortKey="L Pez Labrador, F Xavier" sort="L Pez Labrador, F Xavier" uniqKey="L Pez Labrador F" first="F Xavier" last="L Pez-Labrador">F Xavier L Pez-Labrador</name></noRegion><name sortKey="Diez Domingo, Javier" sort="Diez Domingo, Javier" uniqKey="Diez Domingo J" first="Javier" last="Díez-Domingo">Javier Díez-Domingo</name><name sortKey="Moya, Andres" sort="Moya, Andres" uniqKey="Moya A" first="Andrés" last="Moya">Andrés Moya</name><name sortKey="Natividad Sancho, Angels" sort="Natividad Sancho, Angels" uniqKey="Natividad Sancho A" first="Angels" last="Natividad-Sancho">Angels Natividad-Sancho</name><name sortKey="Puig Barbera, Joan" sort="Puig Barbera, Joan" uniqKey="Puig Barbera J" first="Joan" last="Puig-Barberà">Joan Puig-Barberà</name><name sortKey="Salvatierra, Karina" sort="Salvatierra, Karina" uniqKey="Salvatierra K" first="Karina" last="Salvatierra">Karina Salvatierra</name></country><country name="Russie"><noRegion><name sortKey="Pisareva, Maria" sort="Pisareva, Maria" uniqKey="Pisareva M" first="Maria" last="Pisareva">Maria Pisareva</name></noRegion><name sortKey="Afanasieva, Olga" sort="Afanasieva, Olga" uniqKey="Afanasieva O" first="Olga" last="Afanasieva">Olga Afanasieva</name><name sortKey="Fadeev, Artem" sort="Fadeev, Artem" uniqKey="Fadeev A" first="Artem" last="Fadeev">Artem Fadeev</name><name sortKey="Grudinin, Mikhail" sort="Grudinin, Mikhail" uniqKey="Grudinin M" first="Mikhail" last="Grudinin">Mikhail Grudinin</name><name sortKey="Komissarov, Andrey" sort="Komissarov, Andrey" uniqKey="Komissarov A" first="Andrey" last="Komissarov">Andrey Komissarov</name><name sortKey="Konovalova, Nadezhda" sort="Konovalova, Nadezhda" uniqKey="Konovalova N" first="Nadezhda" last="Konovalova">Nadezhda Konovalova</name><name sortKey="Sominina, Anna" sort="Sominina, Anna" uniqKey="Sominina A" first="Anna" last="Sominina">Anna Sominina</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeEspagneV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000146 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000146 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeEspagneV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27690141
|texte= Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27690141" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeEspagneV1
| This area was generated with Dilib version V0.6.37. |  |